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The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers

Voltage-gated ion channels couple conformational change(s) of the voltage-sensing domain to those of the opening of an intracellular gate to allow ionic conduction. Much larger positive potentials are required to couple these conformational changes to the opening of the gate of Shaker K(+) channels...

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Detalles Bibliográficos
Autores principales: Gagnon, Dominique G., Bezanilla, Francisco
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964516/
https://www.ncbi.nlm.nih.gov/pubmed/20974773
http://dx.doi.org/10.1085/jgp.201010487