Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics

The hallmark of many intracellular pore blockers such as tetra-alkylammonium compounds and local anesthetics is their ability to allosterically modify the movement of the voltage sensors in voltage-dependent ion channels. For instance, the voltage sensor of domain III is specifically stabilized in t...

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Detalles Bibliográficos
Autores principales: Arcisio-Miranda, Manoel, Muroi, Yukiko, Chowdhury, Sandipan, Chanda, Baron
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964522/
https://www.ncbi.nlm.nih.gov/pubmed/20937693
http://dx.doi.org/10.1085/jgp.201010438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964522/
https://www.ncbi.nlm.nih.gov/pubmed/20937693
http://dx.doi.org/10.1085/jgp.201010438

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