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Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics
The hallmark of many intracellular pore blockers such as tetra-alkylammonium compounds and local anesthetics is their ability to allosterically modify the movement of the voltage sensors in voltage-dependent ion channels. For instance, the voltage sensor of domain III is specifically stabilized in t...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964522/ https://www.ncbi.nlm.nih.gov/pubmed/20937693 http://dx.doi.org/10.1085/jgp.201010438 |