LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity

BACKGROUND: Germline mutations in LKB1 result in Peutz-Jeghers Syndrome characterized by intestinal hamartomas and increased incidence of epithelial cancers. LKB1 encodes a serine/threonine kinase that plays an important role in regulating energy metabolism through the AMPK/mTOR signaling pathway. I...

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Detalles Bibliográficos
Autores principales: Xu, Xiaojian, Omelchenko, Tatiana, Hall, Alan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964536/
https://www.ncbi.nlm.nih.gov/pubmed/20939895
http://dx.doi.org/10.1186/1471-2121-11-77

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964536/
https://www.ncbi.nlm.nih.gov/pubmed/20939895
http://dx.doi.org/10.1186/1471-2121-11-77

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