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The apoptotic response in HCT116(BAX-/- )cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein
BACKGROUND: Many chemotherapeutic agents promote tumor cell death by activating the intrinsic pathway of apoptosis. Intrinsic apoptosis involves permeabilization of the mitochondrial outer membrane and the release of cytochrome c, a process that is controlled by proteins of the BCL2 gene family. Che...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964639/ https://www.ncbi.nlm.nih.gov/pubmed/20942963 http://dx.doi.org/10.1186/1471-2407-10-554 |