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A mutational analysis and molecular dynamics simulation of quinolone resistance proteins QnrA1 and QnrC from Proteus mirabilis

BACKGROUND: The first report on the transferable, plasmid-mediated quinolone-resistance determinant qnrA1 was in 1998. Since then, qnr alleles have been discovered worldwide in clinical strains of Gram-negative bacilli. Qnr proteins confer quinolone resistance, and belong to the pentapeptide repeat...

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Detalles Bibliográficos
Autores principales: Guo, Qinglan, Weng, Jingwei, Xu, Xiaogang, Wang, Minghua, Wang, Xiaoying, Ye, Xinyu, Wang, Wenning, Wang, Minggui
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964730/
https://www.ncbi.nlm.nih.gov/pubmed/20932305
http://dx.doi.org/10.1186/1472-6807-10-33