Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases

Decreased activity of the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDHC) in brain accompanies neurodegenerative diseases. To reveal molecular mechanisms of this association, we treated rats with a specific inhibitor of OGDHC, succinyl phosphonate, or exposed them to hypoxic stress. In ma...

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Detalles Bibliográficos
Autores principales: Trofimova, L., Lovat, M., Groznaya, A., Efimova, E., Dunaeva, T., Maslova, M., Graf, A., Bunik, V.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964918/
https://www.ncbi.nlm.nih.gov/pubmed/21049004
http://dx.doi.org/10.4061/2010/749061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964918/
https://www.ncbi.nlm.nih.gov/pubmed/21049004
http://dx.doi.org/10.4061/2010/749061

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