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Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice
BACKGROUND: Sunitinib, a tyrosine kinase inhibitor to treat GIST and mRCC may interact with paracetamol as both undergo P450 mediated biotransformation and P-glycoprotein transport. This study evaluates the effects of sunitinib-paracetamol coadministration on liver and renal function biomarkers and...
Autores principales: | Lim, Adeline YL, Segarra, Ignacio, Chakravarthi, Srikumar, Akram, Sufyan, Judson, John P |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965131/ https://www.ncbi.nlm.nih.gov/pubmed/20950441 http://dx.doi.org/10.1186/1471-2210-10-14 |
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