Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner

BACKGROUND: Parkinson's disease is characterized by the presence of cytoplasmic inclusions, known as Lewy bodies, containing both aggregated α-synuclein and its interaction partner, synphilin-1. While synphilin-1 is known to accelerate inclusion formation by α-synuclein in mammalian cells, its...

Descripción completa

Detalles Bibliográficos
Autores principales: Büttner, Sabrina, Delay, Charlotte, Franssens, Vanessa, Bammens, Tine, Ruli, Doris, Zaunschirm, Sandra, de Oliveira, Rita Machado, Outeiro, Tiago Fleming, Madeo, Frank, Buée, Luc, Galas, Marie-Christine, Winderickx, Joris
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965147/
https://www.ncbi.nlm.nih.gov/pubmed/21060871
http://dx.doi.org/10.1371/journal.pone.0013700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965147/
https://www.ncbi.nlm.nih.gov/pubmed/21060871
http://dx.doi.org/10.1371/journal.pone.0013700

Ejemplares similares