Cargando…
Synthesis and characterization of oligodeoxyribonucleotides containing a site-specifically incorporated N(6)-carboxymethyl-2′-deoxyadenosine or N(4)-carboxymethyl-2′-deoxycytidine
Humans are exposed to both endogenous and exogenous N-nitroso compounds (NOCs), and many NOCs can be metabolically activated to generate a highly reactive species, diazoacetate, which is capable of inducing carboxymethylation of nucleobases in DNA. Here we report, for the first time, the chemical sy...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965219/ https://www.ncbi.nlm.nih.gov/pubmed/20507914 http://dx.doi.org/10.1093/nar/gkq458 |