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Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
Pre-mRNA splicing is catalyzed by the large ribonucleoprotein spliceosome. Spliceosome assembly is a highly dynamic process in which the complex transitions through a number of intermediates. Recently, the potent anti-tumor compound Spliceostatin A (SSA) was shown to inhibit splicing and to interact...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965229/ https://www.ncbi.nlm.nih.gov/pubmed/20529876 http://dx.doi.org/10.1093/nar/gkq494 |