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Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

Pre-mRNA splicing is catalyzed by the large ribonucleoprotein spliceosome. Spliceosome assembly is a highly dynamic process in which the complex transitions through a number of intermediates. Recently, the potent anti-tumor compound Spliceostatin A (SSA) was shown to inhibit splicing and to interact...

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Detalles Bibliográficos
Autores principales:	Roybal, Gabriel A., Jurica, Melissa S.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965229/ https://www.ncbi.nlm.nih.gov/pubmed/20529876 http://dx.doi.org/10.1093/nar/gkq494

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