Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor

Gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor superfamily, has been utilized for receptor-mediated targeting of imaging and therapeutic agents; here we extend its use to oligonucleotide delivery. A splice-shifting antisense oligonucleotide was conjugated to a...

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Detalles Bibliográficos
Autores principales: Ming, Xin, Alam, Md Rowshon, Fisher, Michael, Yan, Yongjun, Chen, Xiaoyuan, Juliano, Rudolph L.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965246/
https://www.ncbi.nlm.nih.gov/pubmed/20551131
http://dx.doi.org/10.1093/nar/gkq534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965246/
https://www.ncbi.nlm.nih.gov/pubmed/20551131
http://dx.doi.org/10.1093/nar/gkq534

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