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Rat traps: filling the toolbox for manipulating the rat genome
The laboratory rat is rapidly gaining momentum as a mammalian genetic model organism. Although traditional forward genetic approaches are well established, recent technological developments have enabled efficient gene targeting and mutant generation. Here we outline the current status, possibilities...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965381/ https://www.ncbi.nlm.nih.gov/pubmed/20887642 http://dx.doi.org/10.1186/gb-2010-11-9-217 |
| _version_ | 1782189509679513600 |
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| author | van Boxtel, Ruben Cuppen, Edwin |
| author_facet | van Boxtel, Ruben Cuppen, Edwin |
| author_sort | van Boxtel, Ruben |
| collection | PubMed |
| description | The laboratory rat is rapidly gaining momentum as a mammalian genetic model organism. Although traditional forward genetic approaches are well established, recent technological developments have enabled efficient gene targeting and mutant generation. Here we outline the current status, possibilities and application of these techniques in the rat. |
| format | Text |
| id | pubmed-2965381 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29653812011-09-29 Rat traps: filling the toolbox for manipulating the rat genome van Boxtel, Ruben Cuppen, Edwin Genome Biol Review The laboratory rat is rapidly gaining momentum as a mammalian genetic model organism. Although traditional forward genetic approaches are well established, recent technological developments have enabled efficient gene targeting and mutant generation. Here we outline the current status, possibilities and application of these techniques in the rat. BioMed Central 2010 2010-09-29 /pmc/articles/PMC2965381/ /pubmed/20887642 http://dx.doi.org/10.1186/gb-2010-11-9-217 Text en Copyright ©2010 BioMed Central Ltd |
| spellingShingle | Review van Boxtel, Ruben Cuppen, Edwin Rat traps: filling the toolbox for manipulating the rat genome |
| title | Rat traps: filling the toolbox for manipulating the rat genome |
| title_full | Rat traps: filling the toolbox for manipulating the rat genome |
| title_fullStr | Rat traps: filling the toolbox for manipulating the rat genome |
| title_full_unstemmed | Rat traps: filling the toolbox for manipulating the rat genome |
| title_short | Rat traps: filling the toolbox for manipulating the rat genome |
| title_sort | rat traps: filling the toolbox for manipulating the rat genome |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965381/ https://www.ncbi.nlm.nih.gov/pubmed/20887642 http://dx.doi.org/10.1186/gb-2010-11-9-217 |
| work_keys_str_mv | AT vanboxtelruben rattrapsfillingthetoolboxformanipulatingtheratgenome AT cuppenedwin rattrapsfillingthetoolboxformanipulatingtheratgenome |