A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

We describe a statistical method for the characterization of genomic aberrations in single nucleotide polymorphism microarray data acquired from cancer genomes. Our approach allows us to model the joint effect of polyploidy, normal DNA contamination and intra-tumour heterogeneity within a single uni...

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Detalles Bibliográficos
Autores principales: Yau, Christopher, Mouradov, Dmitri, Jorissen, Robert N, Colella, Stefano, Mirza, Ghazala, Steers, Graham, Harris, Adrian, Ragoussis, Jiannis, Sieber, Oliver, Holmes, Christopher C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965384/
https://www.ncbi.nlm.nih.gov/pubmed/20858232
http://dx.doi.org/10.1186/gb-2010-11-9-r92

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965384/
https://www.ncbi.nlm.nih.gov/pubmed/20858232
http://dx.doi.org/10.1186/gb-2010-11-9-r92

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