Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

Amyotrophic lateral sclerosis (ALS) is a devastating human neurodegenerative disease. The causes of ALS are poorly understood, although the protein TDP-43 has been suggested to play a critical role in disease pathogenesis. Here we show that Ataxin-2, a polyglutamine (polyQ) protein mutated in spinoc...

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Detalles Bibliográficos
Autores principales: Elden, Andrew C., Kim, Hyung-Jun, Hart, Michael P., Chen-Plotkin, Alice S., Johnson, Brian S., Fang, Xiaodong, Armakola, Maria, Geser, Felix, Greene, Robert, Lu, Min Min, Padmanabhan, Arun, Clay, Dana, McCluskey, Leo, Elman, Lauren, Juhr, Denise, Gruber, Peter J., Rüb, Udo, Auburger, Georg, Trojanowski, John Q., Lee, Virginia M.-Y., Van Deerlin, Vivianna M., Bonini, Nancy M., Gitler, Aaron D.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965417/
https://www.ncbi.nlm.nih.gov/pubmed/20740007
http://dx.doi.org/10.1038/nature09320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965417/
https://www.ncbi.nlm.nih.gov/pubmed/20740007
http://dx.doi.org/10.1038/nature09320

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