MRE11 Function in Response to Topoisomerase Poisons Is Independent of its Function in Double-Strand Break Repair in Saccharomyces cerevisiae

Camptothecin (CPT) and etoposide (ETP) trap topoisomerase-DNA covalent intermediates, resulting in formation of DNA damage that can be cytotoxic if unrepaired. CPT and ETP are prototypes for molecules widely used in chemotherapy of cancer, so defining the mechanisms for repair of damage induced by t...

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Detalles Bibliográficos
Autores principales: Hamilton, Nicolle K., Maizels, Nancy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965672/
https://www.ncbi.nlm.nih.gov/pubmed/21060845
http://dx.doi.org/10.1371/journal.pone.0015387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965672/
https://www.ncbi.nlm.nih.gov/pubmed/21060845
http://dx.doi.org/10.1371/journal.pone.0015387

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