Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene

Each unit of the D4Z4 macrosatellite repeat contains a retrotransposed gene encoding the DUX4 double-homeobox transcription factor. Facioscapulohumeral dystrophy (FSHD) is caused by deletion of a subset of the D4Z4 units in the subtelomeric region of chromosome 4. Although it has been reported that...

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Detalles Bibliográficos
Autores principales: Snider, Lauren, Geng, Linda N., Lemmers, Richard J. L. F., Kyba, Michael, Ware, Carol B., Nelson, Angelique M., Tawil, Rabi, Filippova, Galina N., van der Maarel, Silvère M., Tapscott, Stephen J., Miller, Daniel G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965761/
https://www.ncbi.nlm.nih.gov/pubmed/21060811
http://dx.doi.org/10.1371/journal.pgen.1001181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965761/
https://www.ncbi.nlm.nih.gov/pubmed/21060811
http://dx.doi.org/10.1371/journal.pgen.1001181

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