A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

The activation of receptor tyrosine kinases, particularly ErbB2, plays an important role in the genesis of breast cancer. ErbB2 kinase activity promotes Ras-mediated stimulation of downstream protein kinase cascades, including the Ras/Raf-1/Mek/extracellular-signal regulated kinase (Erk) pathway, le...

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Detalles Bibliográficos
Autores principales: Arias-Romero, Luis E., Villamar-Cruz, Olga, Pacheco, Almudena, Kosoff, Rachelle, Huang, Min, Muthuswamy, Senthil K., Chernoff, Jonathan
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965784/
https://www.ncbi.nlm.nih.gov/pubmed/20711231
http://dx.doi.org/10.1038/onc.2010.318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965784/
https://www.ncbi.nlm.nih.gov/pubmed/20711231
http://dx.doi.org/10.1038/onc.2010.318

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