Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR

BACKGROUND: To determine the mechanisms associated with loss of androgen dependency and disease progression in prostate cancer (PCa), we investigated the relationship between the androgen receptor (AR) and mTOR pathways and the impact of inhibiting both pathways in androgen-dependent and castration-...

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Detalles Bibliográficos
Autores principales: Schayowitz, A, Sabnis, G, Goloubeva, O, Njar, V C O, Brodie, A M H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965879/
https://www.ncbi.nlm.nih.gov/pubmed/20842117
http://dx.doi.org/10.1038/sj.bjc.6605882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965879/
https://www.ncbi.nlm.nih.gov/pubmed/20842117
http://dx.doi.org/10.1038/sj.bjc.6605882

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