One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

[Image: see text] The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual screening campaign for fragments inhibiting PTR1 was carried out. Two novel chemical series were identified containing aminobenzothiazole and aminobenzi...

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Detalles Bibliográficos
Autores principales: Mpamhanga, Chidochangu P., Spinks, Daniel, Tulloch, Lindsay B., Shanks, Emma J., Robinson, David A., Collie, Iain T., Fairlamb, Alan H., Wyatt, Paul G., Frearson, Julie A., Hunter, William N., Gilbert, Ian H., Brenk, Ruth
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966039/
https://www.ncbi.nlm.nih.gov/pubmed/19527033
http://dx.doi.org/10.1021/jm900414x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966039/
https://www.ncbi.nlm.nih.gov/pubmed/19527033
http://dx.doi.org/10.1021/jm900414x

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