Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas

BACKGROUND: Glioma is the most commonly diagnosed primary brain tumor and is characterized by invasive and infiltrative behavior. uPAR and cathepsin B are known to be overexpressed in high-grade gliomas and are strongly correlated with invasive cancer phenotypes. METHODOLOGY/PRINCIPAL FINDINGS: In t...

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Detalles Bibliográficos
Autores principales: Malla, Ramarao, Gopinath, Sreelatha, Alapati, Kiranmai, Gondi, Christopher S., Gujrati, Meena, Dinh, Dzung H., Mohanam, Sanjeeva, Rao, Jasti S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966405/
https://www.ncbi.nlm.nih.gov/pubmed/21060833
http://dx.doi.org/10.1371/journal.pone.0013731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966405/
https://www.ncbi.nlm.nih.gov/pubmed/21060833
http://dx.doi.org/10.1371/journal.pone.0013731

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