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Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
BACKGROUND: Glioma is the most commonly diagnosed primary brain tumor and is characterized by invasive and infiltrative behavior. uPAR and cathepsin B are known to be overexpressed in high-grade gliomas and are strongly correlated with invasive cancer phenotypes. METHODOLOGY/PRINCIPAL FINDINGS: In t...
Autores principales: | Malla, Ramarao, Gopinath, Sreelatha, Alapati, Kiranmai, Gondi, Christopher S., Gujrati, Meena, Dinh, Dzung H., Mohanam, Sanjeeva, Rao, Jasti S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966405/ https://www.ncbi.nlm.nih.gov/pubmed/21060833 http://dx.doi.org/10.1371/journal.pone.0013731 |
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