Cargando…

Characterisation of Muta™Mouse λgt10-lacZ transgene: evidence for in vivo rearrangements

The multicopy λgt10-lacZ transgene shuttle vector of Muta™Mouse serves as an important tool for genotoxicity studies. Here, we describe a model for λgt10-lacZ transgene molecular structure, based on characterisation of transgenes recovered from animals of our intramural breeding colony. Unique nucle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shwed, Philip S., Crosthwait, Jennifer, Douglas, George R., Seligy, Vern L.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966988/ https://www.ncbi.nlm.nih.gov/pubmed/20724577 http://dx.doi.org/10.1093/mutage/geq048

Ejemplares similares

Induction of lacZ Mutations in Muta™Mouse Primary Hepatocytes
por: Chen, Guosheng, et al.
Publicado: (2010)

Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse
por: Lemieux, Christine L, et al.
Publicado: (2011)

The functional mutational landscape of the lacZ gene
por: Beal, Marc A., et al.
Publicado: (2023)

Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone
por: White, Paul A, et al.
Publicado: (2017)

Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig‐a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells
por: Maurice, Clotilde, et al.
Publicado: (2019)

Sublinear response in lacZ mutant frequency of Muta(™)Mouse spermatogonial stem cells after low dose subchronic exposure to N‐ethyl‐N‐nitrosourea
por: O'Brien, Jason M., et al.
Publicado: (2015)

Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease
por: Mersmann, Nadine, et al.
Publicado: (2011)

Boundaries in metagenomic screenings using lacZα-based vectors
por: Alves, Luana de Fátima, et al.
Publicado: (2020)

Improved methods for detection of β-galactosidase (lacZ) activity in hard tissue
por: Shimada, Akemi, et al.
Publicado: (2012)

The use of lacZ marker in enumeration of Azotobacter chroococcum in carrier based inoculants
por: Solanki, Manu, et al.
Publicado: (2014)

A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice
Publicado: (1993)

Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing
por: Beal, Marc A., et al.
Publicado: (2015)

Optimized immunofluorescence staining protocol for identifying resident mesenchymal stem cells in bone using LacZ transgenic mice
por: Zheng, Chen-Xi, et al.
Publicado: (2022)

Systemic RNAi Delivery to the Muscles of ROSA26 Mice Reduces lacZ Expression
por: Wei, Jessica, et al.
Publicado: (2014)

A gene expression resource generated by genome-wide lacZ profiling in the mouse
por: Tuck, Elizabeth, et al.
Publicado: (2015)

Activatable Photosensitizer for Targeted Ablation of lacZ-Positive Cells with Single-Cell Resolution
por: Chiba, Mayumi, et al.
Publicado: (2019)

Physiologically Aggregated LacZ Applied in Trehalose Galactosylation in a Recycled Batch Mode
por: Belkova, Martina, et al.
Publicado: (2023)

A plasmid-based lacZα gene assay for DNA polymerase fidelity measurement
por: Keith, Brian J., et al.
Publicado: (2013)

Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease
por: Armit, Chris
Publicado: (2015)

Protocol to visualize CD11c(+) cells in atherosclerosis using LacZ reporter mice
por: Sauter, Manuela, et al.
Publicado: (2022)

BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter
por: Gebhard, Sonja, et al.
Publicado: (2006)

Effect of the Steroid K-canrenoate on hsp70 Expression and Tissue Damage in Transgenic Drosophila melanogaster (hsp70-lacZ) Bg (9)
por: Siddique, Yasir Hasan, et al.
Publicado: (2012)

Quantification of prefrontal cortical neuronal ensembles following conditioned fear learning in a Fos-LacZ transgenic rat with photoacoustic imaging in Vivo
por: Matchynski, James I., et al.
Publicado: (2023)

A GFP-lacZ Bicistronic Reporter System for Promoter Analysis in Environmental Gram-Negative Bacteria
por: Silva-Rocha, Rafael, et al.
Publicado: (2012)

A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines
por: West, David B., et al.
Publicado: (2015)

Construction of a RFP-lacZα bicistronic reporter system and its application in lead biosensing
por: Hui, Chang-ye, et al.
Publicado: (2020)

LacZ‐reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus
por: Puelles, Luis, et al.
Publicado: (2020)

Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene
por: Sah, Rajiv Kumar, et al.
Publicado: (2021)

Mutagenicity of the peroxisome proliferators clofibrate, Wyeth 14,643 and di-2-ethylhexyl phthalate in the lacZ plasmid-based transgenic mouse mutation assay
por: Boerrigter, Michaël ETI
Publicado: (2004)

Toxic Potential of Synthesized Graphene Zinc Oxide Nanocomposite in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ)Bg (9)
por: Siddique, Yasir Hasan, et al.
Publicado: (2014)

Evaluation of the Toxic Potential of Graphene Copper Nanocomposite (GCNC) in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ)Bg(9)
por: Siddique, Yasir Hasan, et al.
Publicado: (2013)

Direct measurement of neuronal ensemble activity using photoacoustic imaging in the stimulated Fos-LacZ transgenic rat brain: A proof-of-principle study
por: Matchynski, James I., et al.
Publicado: (2021)

Production of LacZ Inducible T Cell Hybridoma Specific for Human and Mouse gp100(25–33) Peptides
por: Cafri, Gal, et al.
Publicado: (2013)

Expression Cloning of Recombinant Escherichia coli lacZ Genes Encoding Cytoplasmic and Nuclear β-galactosidase Variants
por: Naderian, Homayoun, et al.
Publicado: (2011)

Various mutations compensate for a deleterious lacZα insert in the replication enhancer of M13 bacteriophage
por: Zygiel, Emily M., et al.
Publicado: (2017)

Effect of methyl methanesulfonate on hsp70 expression and tissue damage in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg (9)
por: Kumar, Vineet, et al.
Publicado: (2011)

Correction: Evaluation of the Toxic Potential of Graphene Copper Nanocomposite (GCNC) in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ)Bg(9)
Publicado: (2014)

Effect of Ku80 Deficiency on Mutation Frequencies and Spectra at a LacZ Reporter Locus in Mouse Tissues and Cells
por: Busuttil, Rita A., et al.
Publicado: (2008)

Topological analysis of a haloacid permease of a Burkholderia sp. bacterium with a PhoA-LacZ reporter
por: Tse, Yuk Man, et al.
Publicado: (2009)

Plasmid-based lacZα assay for DNA polymerase fidelity: application to archaeal family-B DNA polymerase
por: Jozwiakowski, Stanislaw K., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_087a1nbqc5vpaqn6kf21jkkadk