Cargando…

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

BACKGROUND: Among the most harmful of all genetic abnormalities that appear in colorectal cancer (CRC) development are mutations of KRAS and its downstream effector BRAF as they result in abnormal extracellular signal-related kinase (ERK) signaling. In a previous report, we had shown that expression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bergeron, Sébastien, Lemieux, Etienne, Durand, Véronique, Cagnol, Sébastien, Carrier, Julie C, Lussier, Jacques G, Boucher, Marie-Josée, Rivard, Nathalie
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967542/ https://www.ncbi.nlm.nih.gov/pubmed/20942929 http://dx.doi.org/10.1186/1476-4598-9-271

Ejemplares similares

Dual‐specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis
por: Beaudry, Katia, et al.
Publicado: (2018)

Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis
por: Bian, Benjamin, et al.
Publicado: (2015)

ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells
por: Paquin, Marie-Christine, et al.
Publicado: (2013)

Regulation of Neutrophil Serine Proteases by Intracellular Serpins
por: Benarafa, Charaf
Publicado: (2015)

Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
por: Lemieux, E, et al.
Publicado: (2015)

Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms
por: Yaron, Jordan R., et al.
Publicado: (2021)

Plant Serpins: Potential Inhibitors of Serine and Cysteine Proteases with Multiple Functions
por: Ferreira, Monaliza Macêdo, et al.
Publicado: (2023)

Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases
por: De Marco Verissimo, Carolina, et al.
Publicado: (2020)

Serine Protease Inhibitor SERPINE2 Reversibly Modulates Murine Sperm Capacitation
por: Li, Sheng-Hsiang, et al.
Publicado: (2018)

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression
por: Langlois, Marie-Josée, et al.
Publicado: (2010)

Species-Specific Serological Detection for Schistosomiasis by Serine Protease Inhibitor (SERPIN) in Multiplex Assay
por: Tanigawa, Chihiro, et al.
Publicado: (2015)

Carbohydrate-controlled serine protease inhibitor (serpin) production in Bifidobacterium longum subsp. longum
por: Duboux, S., et al.
Publicado: (2021)

Serpins: Genome-Wide Characterisation and Expression Analysis of the Serine Protease Inhibitor Family in Triticum aestivum
por: Benbow, Harriet R., et al.
Publicado: (2019)

SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response
por: Majoros, Hajnalka, et al.
Publicado: (2021)

Involvement of the Serine Protease Inhibitor, SERPINE2, and the Urokinase Plasminogen Activator in Cumulus Expansion and Oocyte Maturation
por: Lu, Chung-Hao, et al.
Publicado: (2013)

Serine protease SP105 activates prophenoloxidase in Asian corn borer melanization, and is regulated by serpin-3
por: Chu, Yuan, et al.
Publicado: (2017)

The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases
por: Kelly-Robinson, Gillian A., et al.
Publicado: (2021)

Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins?
por: Gremski, Luiza Helena, et al.
Publicado: (2021)

Spatiotemporal expression of the serine protease inhibitor, SERPINE2, in the mouse placenta and uterus during the estrous cycle, pregnancy, and lactation
por: Chern, Schu-Rern, et al.
Publicado: (2010)

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
por: Vicuña, Lucas, et al.
Publicado: (2015)

RNAi-mediated silencing of Trichinella spiralis serpin-type serine protease inhibitors results in a reduction in larval infectivity
por: Yi, Nana, et al.
Publicado: (2020)

The under‐appreciated world of the serpin family of serine proteinase inhibitors
por: Bouton, Marie‐Christine, et al.
Publicado: (2023)

The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes
por: Kryvalap, Yury, et al.
Publicado: (2022)

Identification of an interaction between calcium-dependent protein kinase 4 (EtCDPK4) and serine protease inhibitor (EtSerpin) in Eimeria tenella
por: Lv, Ling, et al.
Publicado: (2018)

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins
por: De Marco Verissimo, Carolina, et al.
Publicado: (2022)

DNA accelerates the protease inhibition of a bacterial serpin chloropin
por: Xu, Jiawei, et al.
Publicado: (2023)

TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC
por: Sun, Huimin, et al.
Publicado: (2022)

Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation
por: Lussier, Carine R., et al.
Publicado: (2010)

Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function
por: Dautin, Nathalie
Publicado: (2010)

Protease: Serpin complexes to assess contact system and intrinsic pathway activation
por: Henderson, Michael W., et al.
Publicado: (2020)

Extracellular: Plasma Membrane Proteases – Serine Proteases
por: Antalis, T.M., et al.
Publicado: (2016)

The role of Serine Proteases and Serine Protease Inhibitors in the migration of Gonadotropin-Releasing Hormone neurons
por: Drapkin, Paola T, et al.
Publicado: (2002)

Ixodes scapularis tick serine proteinase inhibitor (serpin) gene family; annotation and transcriptional analysis
por: Mulenga, Albert, et al.
Publicado: (2009)

Loss of PTEN Signaling in Foxl1(+) Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice
por: Langlois, Marie-Josée, et al.
Publicado: (2019)

Serine Proteases of Parasitic Helminths
por: Yang, Yong, et al.
Publicado: (2015)

Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18
por: Guo, Peng-Chao, et al.
Publicado: (2015)

Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function
por: Lahey, Kelcie A., et al.
Publicado: (2017)

Characterization of Protein Z-Dependent Protease Inhibitor/Antithrombin Chimeras Provides Insight into the Serpin Specificity of Coagulation Proteases
por: Yang, Likui, et al.
Publicado: (2017)

Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte–Induced Apoptosis: Differential Modulation by T Helper Type 1 and Type 2 Cells
por: Medema, Jan Paul, et al.
Publicado: (2001)

Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis
por: Manton, K J, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_19r3dnqmp2052p8icda106jafu