Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line

BACKGROUND: TPC-1 is a papillary thyroid carcinoma (PTC)-derived cell line that spontaneously expresses the oncogene RET/PTC1. TPC-1 treated with the RET/PTC1 inhibitor RPI-1 displayed a cytostatic and reversible inhibition of cell proliferation and a strong activation of focal adhesion kinase (FAK)...

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Detalles Bibliográficos
Autores principales: Caccia, Dario, Miccichè, Francesca, Cassinelli, Giuliana, Mondellini, Piera, Casalini, Patrizia, Bongarzone, Italia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967544/
https://www.ncbi.nlm.nih.gov/pubmed/20955590
http://dx.doi.org/10.1186/1476-4598-9-278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967544/
https://www.ncbi.nlm.nih.gov/pubmed/20955590
http://dx.doi.org/10.1186/1476-4598-9-278

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