(2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide

The asymmetric unit of the title compound, C(24)H(18)F(2)N(4)OS, contains two crystallographically independent mol­ecules, A and B, which are linked into two chains of A and B mol­ecules by inter­molecular N—H⋯O hydrogen bonds. The three-dimensional network is stabilized by π–π inter­actions between...

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Autores principales: Selig, Roland, Schollmeyer, Dieter, Stegmiller, Thomas, Albrecht, Wolfgang, Laufer, Stefan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971986/
https://www.ncbi.nlm.nih.gov/pubmed/21578977
http://dx.doi.org/10.1107/S1600536809051010
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author Selig, Roland
Schollmeyer, Dieter
Stegmiller, Thomas
Albrecht, Wolfgang
Laufer, Stefan
author_facet Selig, Roland
Schollmeyer, Dieter
Stegmiller, Thomas
Albrecht, Wolfgang
Laufer, Stefan
author_sort Selig, Roland
collection PubMed
description The asymmetric unit of the title compound, C(24)H(18)F(2)N(4)OS, contains two crystallographically independent mol­ecules, A and B, which are linked into two chains of A and B mol­ecules by inter­molecular N—H⋯O hydrogen bonds. The three-dimensional network is stabilized by π–π inter­actions between the pyridine rings and phenyl rings of different residues, with centroid–centroid distances of 3.793 (1) and 3.666 (2) Å. The mol­ecular conformation is stabilized by intra­molecular N—H⋯F hydrogen bonds (2.15/2.15Å). The imidazole rings make dihedral angles of 39.5 (2)/38.5 (2) and 31.8 (2)/33.2 (2)° with the 4-fluoro­phenyl rings and the pyridine rings, respectively. The methyl group of molecule A is disorderd in a 0.60:0.40 ratio.
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spelling pubmed-29719862010-12-30 (2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide Selig, Roland Schollmeyer, Dieter Stegmiller, Thomas Albrecht, Wolfgang Laufer, Stefan Acta Crystallogr Sect E Struct Rep Online Organic Papers The asymmetric unit of the title compound, C(24)H(18)F(2)N(4)OS, contains two crystallographically independent mol­ecules, A and B, which are linked into two chains of A and B mol­ecules by inter­molecular N—H⋯O hydrogen bonds. The three-dimensional network is stabilized by π–π inter­actions between the pyridine rings and phenyl rings of different residues, with centroid–centroid distances of 3.793 (1) and 3.666 (2) Å. The mol­ecular conformation is stabilized by intra­molecular N—H⋯F hydrogen bonds (2.15/2.15Å). The imidazole rings make dihedral angles of 39.5 (2)/38.5 (2) and 31.8 (2)/33.2 (2)° with the 4-fluoro­phenyl rings and the pyridine rings, respectively. The methyl group of molecule A is disorderd in a 0.60:0.40 ratio. International Union of Crystallography 2009-11-28 /pmc/articles/PMC2971986/ /pubmed/21578977 http://dx.doi.org/10.1107/S1600536809051010 Text en © Selig et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Selig, Roland
Schollmeyer, Dieter
Stegmiller, Thomas
Albrecht, Wolfgang
Laufer, Stefan
(2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide
title (2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide
title_full (2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide
title_fullStr (2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide
title_full_unstemmed (2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide
title_short (2Z)-2-Fluoro-N-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1H-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide
title_sort (2z)-2-fluoro-n-{4-[5-(4-fluoro­phen­yl)-2-methyl­sulfanyl-1h-imidazol-4-yl]-2-pyrid­yl}-3-phenyl­acrylamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971986/
https://www.ncbi.nlm.nih.gov/pubmed/21578977
http://dx.doi.org/10.1107/S1600536809051010
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