The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

BACKGROUND: Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphoblastic leukemia (ALL) cells are still unclear. METHODS: ALL cell lines (SEM, RS4...

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Detalles Bibliográficos
Autores principales: Schult, Catrin, Dahlhaus, Meike, Ruck, Sabine, Sawitzky, Mandy, Amoroso, Francesca, Lange, Sandra, Etro, Daniela, Glass, Aenne, Fuellen, Georg, Boldt, Sonja, Wolkenhauer, Olaf, Neri, Luca Maria, Freund, Mathias, Junghanss, Christian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972283/
https://www.ncbi.nlm.nih.gov/pubmed/20950443
http://dx.doi.org/10.1186/1471-2407-10-560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972283/
https://www.ncbi.nlm.nih.gov/pubmed/20950443
http://dx.doi.org/10.1186/1471-2407-10-560

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