Cargando…
Ascl1a regulates Müller glia dedifferentiation and retina regeneration via a Lin-28-dependent, let-7 miRNA signaling pathway
Unlike mammals, teleost fish mount a robust regenerative response to retinal injury that culminates in restoration of visual function1, 2. This regenerative response relies on Müller glia (MG) dedifferentiation into a cycling population of progenitor cells. However, the mechanism underlying this ded...
Autores principales: | Ramachandran, Rajesh, Fausett, Blake V., Goldman, Daniel |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972404/ https://www.ncbi.nlm.nih.gov/pubmed/20935637 http://dx.doi.org/10.1038/ncb2115 |
Ejemplares similares
-
Involvement of HB-EGF/Ascl1/Lin28a Genes in Dedifferentiation of Adult Mammalian Müller Glia
por: Stanchfield, Megan L., et al.
Publicado: (2020) -
Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish
por: Mitra, Soumitra, et al.
Publicado: (2018) -
miRNAs and Müller Glia Reprogramming During Retina Regeneration
por: Konar, Gregory J., et al.
Publicado: (2021) -
Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina
por: Salman, Ahmed, et al.
Publicado: (2021) -
Photobiomodulation therapy activates YAP and triggers proliferation and dedifferentiation of Müller glia in mammalian retina
por: Kim, Seo-Yeon, et al.
Publicado: (2023)