Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction

ABSTRACT: Synaptic dysfunction is widely thought to be a pathogenic precursor to neurodegeneration in Alzheimer’s disease (AD), and the extent of synaptic loss provides the best correlate for the severity of dementia in AD patients. Presenilins 1 and 2 are the major causative genes of early-onset fa...

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Detalles Bibliográficos
Autores principales: Zhang, Dawei, Zhang, Chen, Ho, Angela, Kirkwood, Alfredo, Südhof, Thomas C, Shen, Jie
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972413/
https://www.ncbi.nlm.nih.gov/pubmed/20854432
http://dx.doi.org/10.1111/j.1471-4159.2010.07011.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972413/
https://www.ncbi.nlm.nih.gov/pubmed/20854432
http://dx.doi.org/10.1111/j.1471-4159.2010.07011.x

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