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Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction

ABSTRACT: Synaptic dysfunction is widely thought to be a pathogenic precursor to neurodegeneration in Alzheimer’s disease (AD), and the extent of synaptic loss provides the best correlate for the severity of dementia in AD patients. Presenilins 1 and 2 are the major causative genes of early-onset fa...

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Detalles Bibliográficos
Autores principales:	Zhang, Dawei, Zhang, Chen, Ho, Angela, Kirkwood, Alfredo, Südhof, Thomas C, Shen, Jie
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972413/ https://www.ncbi.nlm.nih.gov/pubmed/20854432 http://dx.doi.org/10.1111/j.1471-4159.2010.07011.x

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