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Structural interpretation of P2X receptor mutagenesis studies on drug action

P2X receptors for ATP are ligand gated cation channels that form from the trimeric assembly of subunits with two transmembrane segments, a large extracellular ligand binding loop, and intracellular amino and carboxy termini. The receptors are expressed throughout the body, involved in functions rang...

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Detalles Bibliográficos
Autor principal: Evans, Richard J
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972645/
https://www.ncbi.nlm.nih.gov/pubmed/20977449
http://dx.doi.org/10.1111/j.1476-5381.2010.00728.x