Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy

A major function of proteasomes and macroautophagy is to eliminate misfolded potentially toxic proteins. Mammalian proteasomes, however, cannot cleave polyglutamine (polyQ) sequences and seem to release polyQ-rich peptides. Puromycin-sensitive aminopeptidase (PSA) is the only cytosolic enzyme able t...

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Detalles Bibliográficos
Autores principales: Menzies, Fiona M., Hourez, Raphael, Imarisio, Sara, Raspe, Marcel, Sadiq, Oana, Chandraratna, Dhia, O'Kane, Cahir, Rock, Kenneth L., Reits, Eric, Goldberg, Alfred L., Rubinsztein, David C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972693/
https://www.ncbi.nlm.nih.gov/pubmed/20829225
http://dx.doi.org/10.1093/hmg/ddq385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972693/
https://www.ncbi.nlm.nih.gov/pubmed/20829225
http://dx.doi.org/10.1093/hmg/ddq385

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