The Caenorhabditis elegans Kinesin-3 Motor UNC-104/KIF1A Is Degraded upon Loss of Specific Binding to Cargo

UNC-104/KIF1A is a Kinesin-3 motor that transports synaptic vesicles from the cell body towards the synapse by binding to PI(4,5)P(2) through its PH domain. The fate of the motor upon reaching the synapse is not known. We found that wild-type UNC-104 is degraded at synaptic regions through the ubiqu...

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Detalles Bibliográficos
Autores principales: Kumar, Jitendra, Choudhary, Bikash C., Metpally, Raghu, Zheng, Qun, Nonet, Michael L., Ramanathan, Sowdhamini, Klopfenstein, Dieter R., Koushika, Sandhya P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973836/
https://www.ncbi.nlm.nih.gov/pubmed/21079789
http://dx.doi.org/10.1371/journal.pgen.1001200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973836/
https://www.ncbi.nlm.nih.gov/pubmed/21079789
http://dx.doi.org/10.1371/journal.pgen.1001200

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