Cortactin Phosphorylated by ERK1/2 Localizes to Sites of Dynamic Actin Regulation and Is Required for Carcinoma Lamellipodia Persistence

BACKGROUND: Tumor cell motility and invasion is governed by dynamic regulation of the cortical actin cytoskeleton. The actin-binding protein cortactin is commonly upregulated in multiple cancer types and is associated with increased cell migration. Cortactin regulates actin nucleation through the ac...

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Detalles Bibliográficos
Autores principales: Kelley, Laura C., Hayes, Karen E., Ammer, Amanda Gatesman, Martin, Karen H., Weed, Scott A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973953/
https://www.ncbi.nlm.nih.gov/pubmed/21079800
http://dx.doi.org/10.1371/journal.pone.0013847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973953/
https://www.ncbi.nlm.nih.gov/pubmed/21079800
http://dx.doi.org/10.1371/journal.pone.0013847

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