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Impaired Thymic Selection and Abnormal Antigen-Specific T Cell Responses in Foxn1(Δ/Δ) Mutant Mice
BACKGROUND: Foxn1(Δ/Δ) mutant mice have a specific defect in thymic development, characterized by a block in TEC differentiation at an intermediate progenitor stage, and blocks in thymocyte development at both the DN1 and DP cell stages, resulting in the production of abnormally functioning T cells...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973975/ https://www.ncbi.nlm.nih.gov/pubmed/21079757 http://dx.doi.org/10.1371/journal.pone.0015396 |