Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

Small molecules stabilize specific protein conformations from a larger ensemble, enabling molecular switches that control diverse cellular functions. We show here that the converse also holds true, where the conformational state of the estrogen receptor can direct distinct orientations of the bound...

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Detalles Bibliográficos
Autores principales: Bruning, John B., Parent, Alex A., Gil, German, Zhao, Min, Nowak, Jason, Pace, Margaret C., Smith, Carolyn L., Afonine, Pavel V., Adams, Paul D., Katzenellenbogen, John A., Nettles, Kendall W.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974172/
https://www.ncbi.nlm.nih.gov/pubmed/20924370
http://dx.doi.org/10.1038/nchembio.451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974172/
https://www.ncbi.nlm.nih.gov/pubmed/20924370
http://dx.doi.org/10.1038/nchembio.451

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