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Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity
Small molecules stabilize specific protein conformations from a larger ensemble, enabling molecular switches that control diverse cellular functions. We show here that the converse also holds true, where the conformational state of the estrogen receptor can direct distinct orientations of the bound...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974172/ https://www.ncbi.nlm.nih.gov/pubmed/20924370 http://dx.doi.org/10.1038/nchembio.451 |