Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1

BACKGROUND: Progranulin (PGRN) encoded by the GRN gene, is a secreted glycoprotein growth factor that has been implicated in many physiological and pathophysiological processes. PGRN haploinsufficiency caused by autosomal dominant mutations within the GRN gene leads to progressive neuronal atrophy i...

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Detalles Bibliográficos
Autores principales: Chitramuthu, Babykumari P, Baranowski, David C, Kay, Denis G, Bateman, Andrew, Bennett, Hugh PJ
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974670/
https://www.ncbi.nlm.nih.gov/pubmed/20946666
http://dx.doi.org/10.1186/1750-1326-5-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974670/
https://www.ncbi.nlm.nih.gov/pubmed/20946666
http://dx.doi.org/10.1186/1750-1326-5-41

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