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Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation

BACKGROUND: Neuropilin is a transmembrane receptor for vascular endothelial growth factor (VEGF) and is expressed in normal endothelial cells and upregulated in cancer cells. Neuropilin-1 (NRP-1) has been shown to promote tumour cell migration and survival in colon cancer in response to VEGF binding...

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Detalles Bibliográficos
Autores principales: Yu, Danny CW, Waby, Jennifer S, Chirakkal, Haridasan, Staton, Carolyn A, Corfe, Bernard M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974727/
https://www.ncbi.nlm.nih.gov/pubmed/20950431
http://dx.doi.org/10.1186/1476-4598-9-276