Calculations of binding affinity between C8-substituted GTP analogs and the bacterial cell-division protein FtsZ

The FtsZ protein is a self-polymerizing GTPase that plays a central role in bacterial cell division. Several C8-substituted GTP analogs are known to inhibit the polymerization of FtsZ by competing for the same binding site as its endogenous activating ligand GTP. Free energy calculations of the rela...

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Detalles Bibliográficos
Autores principales: Hritz, Jozef, Läppchen, Tilman, Oostenbrink, Chris
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975913/
https://www.ncbi.nlm.nih.gov/pubmed/20559630
http://dx.doi.org/10.1007/s00249-010-0614-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975913/
https://www.ncbi.nlm.nih.gov/pubmed/20559630
http://dx.doi.org/10.1007/s00249-010-0614-y

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