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Calculations of binding affinity between C8-substituted GTP analogs and the bacterial cell-division protein FtsZ
The FtsZ protein is a self-polymerizing GTPase that plays a central role in bacterial cell division. Several C8-substituted GTP analogs are known to inhibit the polymerization of FtsZ by competing for the same binding site as its endogenous activating ligand GTP. Free energy calculations of the rela...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975913/ https://www.ncbi.nlm.nih.gov/pubmed/20559630 http://dx.doi.org/10.1007/s00249-010-0614-y |