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Mantle cell lymphoma salvage regimen: synergy between a reprogrammed oncolytic virus and two chemotherapeutics

MV-PNP H(blind)antiCD20 is a CD20-targeted and prodrug convertase-armed measles virus (MV) that temporarily controls growth of lymphoma xenografts in SCID mice in combination with fludarabine phosphate. Herein, we examine the replication of this targeted virus and of a vaccine-lineage MV in disease...

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Detalles Bibliográficos
Autores principales: Ungerechts, Guy, Frenzke, Marie E, Yaiw, Koon-Chu, Miest, Tanner, Johnston, Patrick B, Cattaneo, Roberto
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976793/
https://www.ncbi.nlm.nih.gov/pubmed/20686506
http://dx.doi.org/10.1038/gt.2010.103