Controlled Crystallization of the Lipophilic Drug Fenofibrate During Freeze-Drying: Elucidation of the Mechanism by In-Line Raman Spectroscopy

We developed a novel process, “controlled crystallization during freeze-drying” to produce drug nanocrystals of poorly water-soluble drugs. This process involves freeze-drying at a relatively high temperature of a drug and a matrix material from a mixture of tertiary butyl alcohol and water, resulti...

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Detalles Bibliográficos
Autores principales: de Waard, Hans, De Beer, Thomas, Hinrichs, Wouter L. J., Vervaet, Chris, Remon, Jean-Paul, Frijlink, Henderik W.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976986/
https://www.ncbi.nlm.nih.gov/pubmed/20625865
http://dx.doi.org/10.1208/s12248-010-9215-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976986/
https://www.ncbi.nlm.nih.gov/pubmed/20625865
http://dx.doi.org/10.1208/s12248-010-9215-z

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