Amyloid-β Oligomer Specificity Mediated by the IgM Isotype – Implications for a Specific Protective Mechanism Exerted by Endogenous Auto-Antibodies

BACKGROUND: Alzheimers disease (AD) has been strongly linked to an anomalous self-assembly of the amyloid-β peptide (Aβ). The correlation between clinical symptoms of AD and Aβ depositions is, however, weak. Instead small and soluble Aβ oligomers are suggested to exert the major pathological effects...

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Detalles Bibliográficos
Autores principales: Lindhagen-Persson, Malin, Brännström, Kristoffer, Vestling, Monika, Steinitz, Michael, Olofsson, Anders
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978096/
https://www.ncbi.nlm.nih.gov/pubmed/21085663
http://dx.doi.org/10.1371/journal.pone.0013928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978096/
https://www.ncbi.nlm.nih.gov/pubmed/21085663
http://dx.doi.org/10.1371/journal.pone.0013928

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