Phenotypic Complexity, Measurement Bias, and Poor Phenotypic Resolution Contribute to the Missing Heritability Problem in Genetic Association Studies

BACKGROUND: The variance explained by genetic variants as identified in (genome-wide) genetic association studies is typically small compared to family-based heritability estimates. Explanations of this ‘missing heritability’ have been mainly genetic, such as genetic heterogeneity and complex (epi-)...

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Detalles Bibliográficos
Autores principales: van der Sluis, Sophie, Verhage, Matthijs, Posthuma, Danielle, Dolan, Conor V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978099/
https://www.ncbi.nlm.nih.gov/pubmed/21085666
http://dx.doi.org/10.1371/journal.pone.0013929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978099/
https://www.ncbi.nlm.nih.gov/pubmed/21085666
http://dx.doi.org/10.1371/journal.pone.0013929

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