Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and anti-tumor efficacy

There is a need to develop more potent oncolytic adenoviruses that exhibit increased anti-tumor activity in patients. The HYPR-Ads are targeted oncolytic adenoviruses that specifically kill tumor cells which express active hypoxia-inducible factor (HIF). While therapeutically efficacious, the HYPR-A...

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Detalles Bibliográficos
Autores principales: Cherry, Tiffani, Longo, Sharon L., Tovar-Spinoza, Zulma, Post, Dawn E.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978277/
https://www.ncbi.nlm.nih.gov/pubmed/20664541
http://dx.doi.org/10.1038/gt.2010.100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978277/
https://www.ncbi.nlm.nih.gov/pubmed/20664541
http://dx.doi.org/10.1038/gt.2010.100

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