Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination

Spontaneous deamination of cytosine to uracil in DNA is a ubiquitous source of C→T mutations, but occurs with a half life of ∼50 000 years. In contrast, cytosine within sunlight induced cyclobutane dipyrimidine dimers (CPD’s), deaminate within hours to days. Methylation of C increases the frequency...

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Detalles Bibliográficos
Autores principales: Cannistraro, Vincent J., Taylor, John-Stephen A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978359/
https://www.ncbi.nlm.nih.gov/pubmed/20601406
http://dx.doi.org/10.1093/nar/gkq582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978359/
https://www.ncbi.nlm.nih.gov/pubmed/20601406
http://dx.doi.org/10.1093/nar/gkq582

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