Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase

Aromatic interactions are well-known players in molecular recognition but their catalytic role in biological systems is less documented. Here, we report that a conserved aromatic stacking interaction between dUTPase and its nucleotide substrate largely contributes to the stabilization of the associa...

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Detalles Bibliográficos
Autores principales: Pecsi, Ildiko, Leveles, Ibolya, Harmat, Veronika, Vertessy, Beata G., Toth, Judit
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978360/
https://www.ncbi.nlm.nih.gov/pubmed/20601405
http://dx.doi.org/10.1093/nar/gkq584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978360/
https://www.ncbi.nlm.nih.gov/pubmed/20601405
http://dx.doi.org/10.1093/nar/gkq584

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