Cargando…
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
Aromatic interactions are well-known players in molecular recognition but their catalytic role in biological systems is less documented. Here, we report that a conserved aromatic stacking interaction between dUTPase and its nucleotide substrate largely contributes to the stabilization of the associa...
| Autores principales: | , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978360/ https://www.ncbi.nlm.nih.gov/pubmed/20601405 http://dx.doi.org/10.1093/nar/gkq584 |